Junko Akada Selected Research

Pancreatic Neoplasms (Pancreatic Cancer)

2/2017	PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells.
12/2015	The Histone Deacetylase Inhibitor Valproic Acid Sensitizes Gemcitabine-Induced Cytotoxicity in Gemcitabine-Resistant Pancreatic Cancer Cells Possibly Through Inhibition of the DNA Repair Protein Gamma-H2AX.
9/2015	PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death.
7/2015	High-mobility Group Box 1 and Mitogen-activated Protein Kinase activated Protein Kinase-2 Are Up-regulated in Gemcitabine-resistant Pancreatic Cancer Cells.
9/2014	Active hexose-correlated compound down-regulates sex-determining region Y-box 2 of pancreatic cancer cells.
1/2014	Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer.
11/2013	Human pancreatic cancer cells with acquired gemcitabine resistance exhibit significant up-regulation of peroxiredoxin-2 compared to sensitive parental cells.
9/2013	Malignant progressive tumor cell clone exhibits significant up-regulation of cofilin-2 and 27-kDa modified form of cofilin-1 compared to regressive clone.
8/2013	Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
11/2012	Proteomic differential display identifies upregulated vinculin as a possible biomarker of pancreatic cancer.

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Junko Akada Research Topics

Disease

10	Infections 01/2022 - 01/2014
10	Pancreatic Neoplasms (Pancreatic Cancer) 02/2017 - 11/2012
9	Neoplasms (Cancer) 01/2019 - 08/2012
4	Stomach Neoplasms (Stomach Cancer) 11/2021 - 01/2014
1	Duodenal Ulcer (Curling's Ulcer) 11/2021
1	Epstein-Barr Virus Infections 11/2021
1	Atrophy 08/2021
1	Inflammation (Inflammations) 01/2019
1	Chronic Progressive Multiple Sclerosis 03/2017
1	Gastritis 01/2017
1	Carcinoma (Carcinomatosis) 12/2016
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 01/2016
1	Ewing Sarcoma (Sarcoma, Ewing) 08/2015
1	Fibrosarcoma 08/2014
1	Hypoxia (Hypoxemia) 01/2014
1	Starvation 01/2014
1	Carcinogenesis 08/2013
1	Malignant Mesothelioma 08/2013
1	Urinary Bladder Neoplasms (Bladder Cancer) 08/2013
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 08/2013
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 08/2013
1	Hepatocellular Carcinoma (Hepatoma) 07/2013

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 12/2019 - 11/2012
7	Gemcitabine FDA Link 02/2017 - 08/2013
5	Biomarkers (Surrogate Marker)IBA 11/2021 - 11/2012
3	AntibodiesIBA 01/2017 - 07/2013
3	Pharmaceutical PreparationsIBA 12/2015 - 11/2013
2	Small Interfering RNA (siRNA)IBA 11/2021 - 12/2016
2	Lactoylglutathione LyaseIBA 08/2014 - 08/2012
1	Metronidazole (Metric)FDA LinkGeneric 01/2022
1	Oncogene Proteins (Oncogene Protein)IBA 11/2021
1	LatexIBA 08/2021
1	Immunoglobulin G (IgG)IBA 07/2021
1	Pepsinogen A (Pepsinogen)IBA 07/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 06/2019
1	Interleukin-8 (Interleukin 8)IBA 06/2019
1	RhodaminesIBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2018
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 04/2018
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 04/2018
1	CaspasesIBA 04/2018
1	DNA (Deoxyribonucleic Acid)IBA 04/2018
1	Clarithromycin (Biaxin)FDA LinkGeneric 05/2017
1	Galectin 3 (LGALS3)IBA 03/2017
1	WortmanninIBA 02/2017
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 02/2017
1	Protein Tyrosine PhosphatasesIBA 12/2016
1	Amino Acids FDA Link 01/2016
1	tranilastIBA 12/2015
1	Valproic Acid (Depakote)FDA LinkGeneric 12/2015
1	Histone Deacetylase InhibitorsIBA 12/2015
1	CalciumIBA 09/2015
1	CGK 733IBA 09/2015
1	HSP27 Heat-Shock ProteinsIBA 07/2015
1	Mitogen-Activated Protein KinasesIBA 07/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2014
1	Active Hexose Correlated CompoundIBA 09/2014
1	PhosphotyrosineIBA 08/2014
1	IsoenzymesIBA 08/2014
1	Myosins (Myosin)IBA 08/2014
1	Peptides (Polypeptides)IBA 08/2014
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 08/2014
1	NM23 Nucleoside Diphosphate KinasesIBA 08/2014
1	Adenylate KinaseIBA 08/2014
1	transcription factor BTF3IBA 08/2014
1	Annexin A1IBA 08/2014
1	Poly (ADP-Ribose) Polymerase-1IBA 01/2014
1	Protein Kinases (Protein Kinase)IBA 01/2014
1	Adenosine Diphosphate (ADP)IBA 01/2014
1	Cofilin 2IBA 09/2013
1	aspartylglutamateIBA 08/2013
1	alanylaspartic acidIBA 08/2013
1	DEAD-box RNA HelicasesIBA 08/2013
1	AutoantibodiesIBA 07/2013
1	VinculinIBA 11/2012
1	GelsIBA 11/2012
1	Pyruvaldehyde (Methylglyoxal)IBA 08/2012
1	EnzymesIBA 08/2012

Therapy/Procedure

2	Therapeutics 05/2017 - 08/2013
1	Drug Therapy (Chemotherapy) 11/2013